OP0047 IDENTIFICATION OF CLINICAL PHENOTYPES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS, PERIPHERAL SPONDYLOARTHRITIS AND PSORIATIC ARTHRITIS ACCORDING TO PERIPHERAL MUSCULOSKELETAL MANIFESTATIONS: A CLUSTER ANALYSIS IN THE INTERNATIONAL ASAS-PERSPA STUDY

Background: Patients with a diagnosis of Spondyloarthritis (SpA) and Psoriatic Arthritis (PsA) may have predominant axial or peripheral symptoms, the frequency distribution these symptoms determine clinical by rheumatologist (“clinical clusters”). Clustering analysis represents an unsupervised exploratory which tries to identify homogeneous groups cases (“statistical clusters”) without prior information about membership for any cases. Objectives: To “statistical clusters” involvement according specific location in whole spectrum SpA PsA (without patients), evaluate whether are agreement “clinical clusters”. Methods: Cross-sectional multicentre study 24 participating countries. Consecutive patients considered their treating as suffering from either PsA, (axSpA) (pSpA) were enrolled. Four different cluster analyses conducted: first one using all musculoskeletal manifestations (i.e., arthritis, enthesitis dactylitis), thereafter each manifestation individually. Multiple correspondence k-means clustering methods used. Distribution characteristics compared across clusters. Results: 4465 included analysis. Two clusters found regard (Fig. 1). Cluster 1 showed low prevalence comparison 2; however, when appeared 1, this was mostly represented arthritis hip, knee ankle, well heel. higher males (63% vs 44%), HLA-B27 positivity (69% 38%) (80% 52%), more frequent axSpA (66% 21%) frequently fulfilling ASAS criteria vs. 41%). 2 psoriasis 25%), (61% 19%), they fulfilled (26% 11%) CASPAR (57% 19%). Figure 1. Three arthritis. Clusters 3 high joint disease, although located predominantly lower limbs 2, upper 3. males, positivity, involvement, presence psoriasis, 3, respectively. dactylitis fulfillment criteria. Information exhibited three groups: very enthesitis, while enthesis Finally, also that dactylitis, toes fingers Conclusion: These results suggest heterogeneous patterns clearly defined groups, confirming clear overlap underlying diagnoses. Acknowledgements: This conducted under umbrella unrestricted grant Abbvie, Pfizer, Lilly, Novartis, UCB, Janssen Merck. Disclosure Interests: None declared